2006年至2013年三级癌症中心癌症患者的症状负担与健康相关生活质量（HRQoL）：一项横断面研究。
Cancer Patients' Symptom Burden and Health-related Quality of Life (HRQoL) at Tertiary Cancer Center from 2006 to 2013: A Cross-sectional Study.
作者信息
Kokkonen Kristiina, Tasmuth Tiina, Lehto Juho T, Kautiainen Hannu, Elme Anneli, Jääskeläinen Anna-Stina, Saarto Tiina
机构信息
Orton Oy and Faculty of Medicine, University of Helsinki, Helsinki, Finland
Helsinki University Hospital, Comprehensive Cancer Center, Department of Palliative Care and Faculty of Medicine, University of Helsinki, Helsinki, Finland.
出版信息
Anticancer Res. 2019 Jan;39(1):271-277. doi: 10.21873/anticanres.13107.
BACKGROUND/AIM: To observe changes in symptoms and health-related quality of life (HRQoL) over 7 years among cancer patients at different stages of the disease.
PATIENTS AND METHODS
This prospective cross-sectional study at the Helsinki University Hospital Cancer Center, was carried out in 2006 and repeated in 2013. All participants filled in the EORTC-QLQ-C30 questionnaire.
RESULTS
Altogether, 581 patients responded (49% in 2006 and 54% in 2013). The disease was local in 51% and advanced in 49% of patients. The HRQoL was significantly lower, except for emotional and cognitive functions, and the symptom burden more severe in advanced cancer. The most prevalent symptoms were fatigue (93% and 85%; moderate/severe 22% and 9%), pain (65% and 47%; moderate/severe 16% and 5%), and insomnia (64% and 60%; moderate/severe 20 and 21%), respectively. No changes in HRQoL or symptoms were found at 7 years.
CONCLUSION
There is a need for early integrated palliative care to improve HRQoL during cancer treatments.
背景/目的：观察不同疾病阶段的癌症患者在7年期间症状及健康相关生活质量（HRQoL）的变化。
患者与方法
这项前瞻性横断面研究于2006年在赫尔辛基大学医院癌症中心开展，并于2013年重复进行。所有参与者均填写了欧洲癌症研究与治疗组织生活质量核心问卷（EORTC-QLQ-C30）。
结果
共有581名患者做出回应（2006年为49%，2013年为54%）。51%的患者疾病处于局部阶段，49%的患者疾病处于晚期。除情感和认知功能外，晚期癌症患者的HRQoL显著更低，症状负担更重。最常见的症状分别是疲劳（93%和85%；中度/重度分别为22%和9%）、疼痛（65%和47%；中度/重度分别为16%和5%）以及失眠（64%和60%；中度/重度分别为20%和21%）。7年期间未发现HRQoL或症状有变化。
结论
需要早期综合姑息治疗以改善癌症治疗期间的HRQoL。
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