Division of Health Science, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
IUBMB Life. 2019 Apr;71(4):516-522. doi: 10.1002/iub.1991. Epub 2018 Dec 27.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD manifests as hepatic lipid accumulation, insulin resistance, and inflammation, and can progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. However, the underlying mechanisms of NAFLD, including those that drive its progression, are unclear. Both liver-resident (Kupffer cells) and recruited macrophages play a crucial role in the development of insulin resistance and NASH. Therefore, NALFD could potentially be ameliorated by modifying the polarization of macrophages/Kupffer cells. Reactive oxygen species induce oxidative stress, which is implicated in the progression of NASH. Micronutrients, including vitamins, are potent antioxidants that exert anti-inflammatory effects, and are used in the treatment of NAFLD. We review here the molecular mechanisms of the pathogenesis of NAFLD and the potential utility of vitamin E in its prevention and/or treatment. © 2018 IUBMB Life, 71(4):516-522, 2019.
非酒精性脂肪性肝病 (NAFLD) 是全球最常见的慢性肝病之一。NAFLD 的表现为肝内脂质积聚、胰岛素抵抗和炎症，可进展为非酒精性脂肪性肝炎 (NASH) 和肝硬化。然而，NAFLD 的潜在机制，包括驱动其进展的机制尚不清楚。肝内固有细胞（库普弗细胞）和募集的巨噬细胞在胰岛素抵抗和 NASH 的发展中起关键作用。因此，通过改变巨噬细胞/库普弗细胞的极化，NAFLD 可能得到改善。活性氧诱导氧化应激，这与 NASH 的进展有关。微量营养素，包括维生素，是有效的抗氧化剂，具有抗炎作用，并用于治疗 NAFLD。我们在此回顾了 NAFLD 发病机制的分子机制以及维生素 E 在其预防和/或治疗中的潜在用途。©2018 IUBMB Life，71(4):516-522，2019。
