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用于预测股骨颈骨折行急性关节置换术后死亡率的合并症指数预测能力低。

Low predictive power of comorbidity indices identified for mortality after acute arthroplasty surgery undertaken for femoral neck fracture.

机构信息

The Swedish Hip Arthroplasty Register, Centre of Registers Västra Götaland, Gothenburg, Sweden; Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

The Swedish Hip Arthroplasty Register, Centre of Registers Västra Götaland, Gothenburg, Sweden; Department of Orthopedics, Hywel Dda University Healthboard, Prince Philip Hospital, Bryngwyn Mawr, Dafen, Llanelli, UK.

出版信息

Bone Joint J. 2019 Jan;101-B(1):104-112. doi: 10.1302/0301-620X.101B1.BJJ-2018-0894.R1.

Abstract

AIMS

Our aim was to examine the Elixhauser and Charlson comorbidity indices, based on administrative data available before surgery, and to establish their predictive value for mortality for patients who underwent hip arthroplasty in the management of a femoral neck fracture.

PATIENTS AND METHODS

We analyzed data from 42 354 patients from the Swedish Hip Arthroplasty Register between 2005 and 2012. Only the first operated hip was included for patients with bilateral arthroplasty. We obtained comorbidity data by linkage from the Swedish National Patient Register, as well as death dates from the national population register. We used univariable Cox regression models to predict mortality based on the comorbidity indices, as well as multivariable regression with age and gender. Predictive power was evaluated by a concordance index, ranging from 0.5 to 1 (with the higher value being the better predictive power). A concordance index less than 0.7 was considered poor. We used bootstrapping for internal validation of the results.

RESULTS

The predictive power of mortality was poor for both the Elixhauser and Charlson comorbidity indices (concordance indices less than 0.7). The Charlson Comorbidity Index was superior to Elixhauser, and a model with age and gender was superior to both indices.

CONCLUSION

Preoperative comorbidity from administrative data did not predict mortality for patients with a hip fracture treated by arthroplasty. This was true even if association on group level existed.

摘要

目的

本研究旨在基于手术前可获得的行政数据,检验 Elixhauser 和 Charlson 合并症指数,并确定其对股骨颈骨折行髋关节置换术患者死亡率的预测价值。

患者与方法

我们分析了 2005 年至 2012 年期间来自瑞典髋关节置换登记处的 42354 例患者的数据。对于行双侧关节置换术的患者,仅纳入初次手术的髋关节。我们通过与瑞典国家患者登记处的链接获取合并症数据,并通过全国人口登记处获取死亡日期。我们使用单变量 Cox 回归模型根据合并症指数预测死亡率,以及使用年龄和性别进行多变量回归。通过一致性指数(范围为 0.5 至 1,值越高表示预测能力越强)评估预测能力。一致性指数小于 0.7 被认为是预测能力差。我们使用自举法对内部分数验证结果进行验证。

结果

Elixhauser 和 Charlson 合并症指数对死亡率的预测能力均较差(一致性指数均小于 0.7)。Charlson 合并症指数优于 Elixhauser,而包含年龄和性别的模型优于这两个指数。

结论

来自行政数据的术前合并症并不能预测行关节置换术的股骨颈骨折患者的死亡率。即使在组水平上存在关联,情况也是如此。

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