Translocation (8;16)(p11;p13) in patients with acute monocytic leukemias. An evolving syndrome?
作者信息
Powell B L, McNay J W, Brown S, Cooper M R, Pettenati M J
机构信息
Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
出版信息
Cancer Genet Cytogenet. 1988 Nov;36(1):109-15. doi: 10.1016/0165-4608(88)90080-5.
The case of a patient with a t(8;16)(p11;p13) chromosomal abnormality and acute myelomonocytic leukemia is described. Review of cases with this translocation showed that 11 of 13 patients had acute monocytic or myelomonocytic leukemia with a high frequency of extramedullary disease and phagocytosis of normal blood cells by the malignant cells. While these patients are not clinically distinct from others with acute monocytic leukemia, the characteristic features of this subset of patients will certainly evolve.
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