肝脏发病机制的自噬分析

Analysis of Autophagy for Liver Pathogenesis.

作者信息

Huda Nazmul, Zou Hui, Yan Shengmin, Khambu Bilon, Yin Xiao-Ming

机构信息

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

College of Veterinary Medicine, Yangzhou University, Yangzhou, People's Republic of China.

出版信息

Methods Mol Biol. 2019;1880:481-489. doi: 10.1007/978-1-4939-8873-0_30.

DOI:10.1007/978-1-4939-8873-0_30

PMID:30610716

Abstract

The autophagy pathway in hepatocytes is well characterized. Autophagy plays a critical role in the normal function of the liver. A growing number of studies suggest that there is a mechanistic relationship between autophagy and the pathogenesis of human diseases including liver diseases. Here we focus on the methods assessing the level of lipids, lipid peroxidation, and lipophagy in the liver, which would be particularly relevant to the study of fatty liver diseases.

摘要

肝细胞中的自噬途径已得到充分表征。自噬在肝脏的正常功能中起着关键作用。越来越多的研究表明，自噬与包括肝脏疾病在内的人类疾病发病机制之间存在机制上的关联。在此，我们重点关注评估肝脏中脂质水平、脂质过氧化和脂质自噬的方法，这些方法对于脂肪肝疾病的研究尤为相关。