Bauer Maria, Bartoli Jaume, Martinez-Chapa Sergio O, Madou Marc
Department of Mechanical and Aerospace Engineering, University of California Irvine, Irvine, CA 92697, USA.
Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA.
Micromachines (Basel). 2019 Jan 7;10(1):31. doi: 10.3390/mi10010031.
Novel biomarkers and lower limits of detection enable improved diagnostics. In this paper we analyze the influence of flow on the lower limit of electrochemical detection on a microfluidic Compact Disc (CD). Implementing wireless transfer of data reduces noise during measurements and allows for real time sensing, demonstrated with the ferri-ferroyanide redox-couple in single and dual mode cyclic voltammetry. The impact of flow on redox-amplification and electrode integration for the lowest limit of detection are discussed.
新型生物标志物和检测下限的降低有助于改进诊断。在本文中,我们分析了流体对微流控光盘(CD)上电化学检测下限的影响。实现数据的无线传输可降低测量过程中的噪声,并实现实时传感,以亚铁氰化铁氧化还原对在单模和双模循环伏安法中的应用为例进行了演示。讨论了流体对氧化还原放大和电极集成以实现最低检测限的影响。