Kettani Assiya El, Jebbar Sanae, Takourt Brahim, Maaloum Fakhreddine, Diraa Othman, Farouqi Brahim, Zerouali Khalid, Filali Kamal Marhoum El
Laboratoire d'Immuno-Sérologie, CHU Ibn Rochd-Casablanca, Maroc.
Service des Maladies Infectieuses, CHU Ibn Rochd-Casablanca, Maroc.
Pan Afr Med J. 2018 Aug 16;30:276. doi: 10.11604/pamj.2018.30.276.13913. eCollection 2018.
This study aims to determine the prevalence of HIV infection among patients hospitalized for tuberculosis in the Division of Infectious Diseases at the Ibn Rochd University Hospital in Casablanca and factors associated with TB-HIV co-infection. We conducted a cross-sectional retrospective study in November 2016. The database of the Division of Infectious Diseases, Laboratory of Microbiology and Immunology at the Ibn Rochd University Hospital was examined. All the patients with tuberculosis confirmed using Lowenstein Jensen culture medium and HIV Infection confirmed using Western Blot test between January 2013 and December 2015 were included. During the study period, 117 cases of tuberculosis were confirmed by culture. Fourty six (39.3%) patients had confirmed HIV infection. Thirty-four co-infected patients (73.9%) had extrapulmonary tuberculosis (this form was associated with co-infection (p=0.04)). All patients underwent TB treatment and anti-retroviral treatment according to the indication. The Evolution was favorable in 32 patients (69.6%) and 10 deaths were recorded (21.7%). Mortality rate was higher in co-infected patients than in TB patients without HIV (8.4%), (p=0.04). This study highlights a relatively high prevalence of HIV infection among tuberculosis patients. TB-HIV co-infection is associated with severe forms of tuberculosis and with an increase in mortality rate among TB patients; hence the importance of strengthening anti-co-infection joint activities.
本研究旨在确定卡萨布兰卡伊本·鲁西德大学医院传染病科因结核病住院患者中艾滋病毒感染的患病率以及与结核-艾滋病毒合并感染相关的因素。我们于2016年11月开展了一项横断面回顾性研究。对伊本·鲁西德大学医院传染病科、微生物学和免疫学实验室的数据库进行了检查。纳入了所有在2013年1月至2015年12月期间使用罗-琴培养基确诊为结核病且使用免疫印迹试验确诊为艾滋病毒感染的患者。在研究期间,通过培养确诊了117例结核病病例。46例(39.3%)患者确诊感染艾滋病毒。34例合并感染患者(73.9%)患有肺外结核病(这种形式与合并感染相关(p=0.04))。所有患者均根据指征接受了结核病治疗和抗逆转录病毒治疗。32例患者(69.6%)病情好转,记录到10例死亡(21.7%)。合并感染患者的死亡率高于未感染艾滋病毒的结核病患者(8.4%),(p=0.04)。本研究突出了结核病患者中艾滋病毒感染的患病率相对较高。结核-艾滋病毒合并感染与严重形式的结核病相关,且会增加结核病患者的死亡率;因此加强抗合并感染联合行动非常重要。