超越软骨修复：骨软骨单位在关节健康与疾病中的作用。

1 Department of Biomedical Sciences, University of Guelph, Guelph, Canada.

2 Department of Clinical Studies, University of Guelph, Guelph, Canada.

Tissue Eng Part B Rev. 2019 Apr;25(2):114-125. doi: 10.1089/ten.TEB.2018.0122.

In this comprehensive review, we are providing a holistic overview of osteochondral tissue development, disease, pain localization, as well as structural evaluation and current repair strategies. This review is intended to serve as a broad introduction to this multidisciplinary research area. It is a thorough examination of the biological aspects of the osteochondral unit from a tissue engineering perspective, highlighting the importance of the subchondral bone in chondral and osteochondral lesion repair and pain relief.

在这篇全面的综述中，我们提供了一个关于骨软骨组织发育、疾病、疼痛定位以及结构评估和当前修复策略的整体概述。这篇综述旨在作为这个多学科研究领域的一个广泛介绍。它从组织工程学的角度彻底检查了骨软骨单位的生物学方面，强调了骨软骨病变修复和缓解疼痛中软骨下骨的重要性。