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[心血管疾病精准医学、基因多态性及病证结合研究]

[Research on Precision Medicine, Gene Polymorphism, and Combination of Disease Identification and Syndrome Typing on Cardiovascular Diseases].

作者信息

Xue Mei, Shi Da-Zhuo, Chen Ke-Ji

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Oct;36(10):1255-1260.

Abstract

With the fusion and application of biological and information technologies in clinical practice, precision medicine has become a more precise positioning and sublimation of individualized medicine. Based on the concept of precision medicine, great developments have taken place in genetic diagnosis and targeted therapy of lung cancer, leukemia, breast cancer and other diseases, genetic diagnosis of cardiovascular diseases, and researches on gene polymorphisms and combination of disease identification and syndrome typing. However, there are still some problems. In the big data analysis era, how to organically combine precision medicine with essence research of syndromes, how to establish a new methodological system based on basic theories of Chinese medicine (CM) in accordance with clinical practice of CM and integrative medicine (IM) are both the difficulties and breakthrough points for Chinese medicine and pharmacy (CMP). They are of significance in promoting modernization of CMP.

摘要

随着生物与信息技术在临床实践中的融合应用,精准医学已成为个性化医疗更精准的定位与升华。基于精准医学理念,肺癌、白血病、乳腺癌等疾病的基因诊断与靶向治疗、心血管疾病的基因诊断以及基因多态性与病证结合分型研究等都取得了很大进展。然而,仍存在一些问题。在大数据分析时代,如何将精准医学与证候本质研究有机结合,如何根据中医及中西医结合临床实践,基于中医基础理论建立新的方法体系,既是中医药学的难点,也是突破点。它们对推动中医药现代化具有重要意义。

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