布地奈德对年幼哮喘儿童肺过度充气的影响。
Effect of budesonide on pulmonary hyperinflation in young asthmatic children.
作者信息
Greenough A, Pool J, Gleeson J G, Price J F
机构信息
Paediatric Respiratory Laboratory, King's College Hospital, London.
出版信息
Thorax. 1988 Nov;43(11):937-8. doi: 10.1136/thx.43.11.937.
In 19 asthmatic children, aged 2-6 years, the effect of six weeks' treatment with inhaled budesonide or placebo on functional residual capacity (FRC--helium dilution) and bronchodilator responsiveness was assessed in a double blind, randomised crossover trial. FRC was increased in most children at the start of treatment. Treatment with budesonide was associated with a reduction in FRC by comparison with placebo (median change 9% v 0%; p less than 0.05). There was a trend towards a greater response to a bronchodilator after budesonide. The results suggest that inhaled corticosteroids reduce hyperinflation in young asthmatic children.
在19名2至6岁的哮喘儿童中，通过双盲随机交叉试验评估了吸入布地奈德或安慰剂治疗六周对功能残气量（FRC——氦稀释法）和支气管扩张剂反应性的影响。大多数儿童在治疗开始时FRC增加。与安慰剂相比，布地奈德治疗使FRC降低（中位变化9%对0%；p<0.05）。使用布地奈德后对支气管扩张剂的反应有增强趋势。结果表明，吸入皮质类固醇可减轻年幼哮喘儿童的肺过度充气。
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