从山楂种子中分离得到的 7 种新型神经保护 sesquineolignans。
Seven new neuroprotective sesquineolignans isolated from the seeds of Crataegus pinnatifida.
机构信息
School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China.
出版信息
Fitoterapia. 2019 Mar;133:225-230. doi: 10.1016/j.fitote.2019.01.008. Epub 2019 Jan 17.
The investigation of the ethanol extract of the seeds of Crataegus pinnatifida led to the isolation of seven new 8-O-4' type sesquineolignans crasesquineolignan A-G (1-7), along with a reported analogue, leptolepisol B (8). The chemical structures of these compounds were elucidated based on complex analysis of their MS, 1D and 2D NMR data. All the isolated compounds were tested for their neuroprotective effects against the damage of human neuroblastoma SH-SY5Y cells induced by HO, and most of them showed significant neuroprotective activity. Among them, compound 4 (77.58%) showed the best protective effect, even better than the positive control (69.26%) at 25 μM.
对山楂种子的乙醇提取物进行研究，分离得到了七种新的 8-O-4'型倍半木脂素类化合物 crasesquineolignan A-G（1-7），以及一个报道的类似物 leptolepisol B（8）。这些化合物的化学结构是根据它们的 MS、1D 和 2D NMR 数据分析得出的。所有分离得到的化合物都进行了神经保护活性测试，以评估它们对 HO 诱导的人神经母细胞瘤 SH-SY5Y 细胞损伤的保护作用，大多数化合物表现出显著的神经保护活性。其中，化合物 4（77.58%）在 25 μM 时表现出最好的保护效果，甚至优于阳性对照（69.26%）。
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