Yang Bing-You, Jiang Hai-Bing, Liu Yan, Chen Jing, Kuang Hai-Xue
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
J Asian Nat Prod Res. 2020 Mar;22(3):257-263. doi: 10.1080/10286020.2018.1553164. Epub 2019 Jan 21.
Two new steroids meteloside F () and meteloside G (), together with six known ones (-), were isolated and identified from the seeds of L. The chemical constituents were isolated by silica gel, ODS chromatogram columns. and preparative HPLC. The structures of these compounds were established by one- and two-dimensional NMR spectra and HR-ESI-MS. The compounds exhibited inhibition on the nitric oxide release of lipopolysaccharide-induced RAW 264.7 cells with IC values from 30.2 to 44.8 μM. [Formula: see text].
从吕宋豆种子中分离并鉴定出两种新的甾体化合物美特洛苷F()和美特洛苷G(),以及六种已知化合物(-)。通过硅胶、ODS色谱柱和制备型高效液相色谱法分离化学成分。这些化合物的结构通过一维和二维核磁共振光谱以及高分辨电喷雾电离质谱确定。这些化合物对脂多糖诱导的RAW 264.7细胞释放一氧化氮具有抑制作用,IC值为30.2至44.8μM。[化学式:见正文]