一锅电化学镍催化的脱羧 Sp-Sp 交叉偶联反应。
One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp-Sp Cross-Coupling.
机构信息
Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive , San Diego , California 92121 , United States.
出版信息
Org Lett. 2019 Feb 1;21(3):816-820. doi: 10.1021/acs.orglett.8b04090. Epub 2019 Jan 23.
A one-pot electrochemical nickel-catalyzed decarboxylative sp-sp cross-coupling reaction has been developed using redox-active esters prepared in situ from alkyl carboxylates and N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (PITU). This undivided cell one-pot method enables C-C bond formation using inexpensive, benchtop-stable reagents with isolated yields up to 95% with good functional group tolerance, which includes nitrile, ketone, ester, alkene and selectivity over other aromatic halogens.
发展了一种一锅电化学镍催化的脱羧 sp-sp 交叉偶联反应，使用原位制备的由烷基羧酸酯和 N-羟基邻苯二甲酰亚胺四氟硼酸酯（PITU）制备的氧化还原活性酯。这种不分流电池一锅法能够使用廉价、台式稳定的试剂进行 C-C 键形成，分离收率高达 95%，具有良好的官能团耐受性，包括腈、酮、酯、烯烃，并对其他芳基卤化物具有选择性。
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