Ore Ayokanmi, Akinloye Oluseyi Adeboye
Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Biochemistry Division, Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, Nigeria.
Medicina (Kaunas). 2019 Jan 24;55(2):26. doi: 10.3390/medicina55020026.
Non-alcoholic fatty liver disease (NAFLD) is a term that covers a range of hepatic disorders involving fat deposits in the liver. NAFLD begins with simple steatosis and progresses into non-alcoholic steatohepatitis (NASH) characterised by inflammation, fibrosis, apoptosis, oxidative stress, lipid peroxidation, mitochondrial dysfunction and release of adipokines and pro-inflammatory cytokines. Oxidative stress and antioxidants are known to play a vital role in the pathogenesis and severity of NAFLD/NASH. A number of oxidative stress and antioxidant markers are employed in the assessment of the pathological state and progression of the disease. In this article, we review several biomarkers of oxidative stress and antioxidants that have been measured at clinical and experimental levels. Also included is a comprehensive description of oxidative stress, sources and contribution to the pathogenesis of NAFLD/NASH.
非酒精性脂肪性肝病（NAFLD）是一个涵盖一系列涉及肝脏脂肪沉积的肝脏疾病的术语。NAFLD始于单纯性脂肪变性，并进展为以炎症、纤维化、细胞凋亡、氧化应激、脂质过氧化、线粒体功能障碍以及脂肪因子和促炎细胞因子释放为特征的非酒精性脂肪性肝炎（NASH）。已知氧化应激和抗氧化剂在NAFLD/NASH的发病机制和严重程度中起着至关重要的作用。许多氧化应激和抗氧化剂标志物被用于评估疾病的病理状态和进展。在本文中，我们综述了在临床和实验水平上测量的几种氧化应激和抗氧化剂生物标志物。还包括对氧化应激、其来源以及对NAFLD/NASH发病机制的贡献的全面描述。
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