长链非编码RNA在子痫前期发病机制中的作用新见解。
New insight into the role of long non-coding RNAs in the pathogenesis of preeclampsia.
作者信息
Moradi Mohammad-Taher, Rahimi Zohreh, Vaisi-Raygani Asad
机构信息
a Medical Biology Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.
b Department of Clinical Biochemistry , Medical School, Kermanshah University of Medical Sciences , Kermanshah , Iran.
出版信息
Hypertens Pregnancy. 2019 Feb;38(1):41-51. doi: 10.1080/10641955.2019.1573252. Epub 2019 Feb 1.
OBJECTIVE
Dysregulation of lncRNAs and the absence of coordination between them could affect the normal placentation, uteroplacental circulation, and endothelial cell function. All these misfunctions can finally lead to preeclampsia.
METHODS
In the present review, we discuss current literature (till May 2018) about lncRNAs expression and function in the placenta, trophoblast cells, and decidua.
RESULTS AND CONCLUSION
It is explained how altered expression of the lncRNAs and abnormal regulation of them affect the risk of preeclampsia. However, the interaction between various lncRNAs and coordinate regulation of them in health and failure of such coordinative mechanisms in diseases such as preeclampsia need to be elucidated.
目的
长链非编码RNA（lncRNAs）的失调及其之间缺乏协调可能会影响正常的胎盘形成、子宫胎盘循环和内皮细胞功能。所有这些功能异常最终都可能导致先兆子痫。
方法
在本综述中，我们讨论了截至2018年5月关于lncRNAs在胎盘、滋养层细胞和蜕膜中的表达及功能的现有文献。
结果与结论
阐述了lncRNAs表达改变及其异常调控如何影响先兆子痫的风险。然而，各种lncRNAs之间的相互作用及其在健康状态下的协调调控以及在先兆子痫等疾病中这种协调机制的失效仍有待阐明。
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