新型海洋来源 sp. ZZ1275 的抗菌吲哚吡嗪 A 和 B
Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated sp. ZZ1275.
机构信息
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China.
出版信息
Mar Drugs. 2019 Feb 1;17(2):89. doi: 10.3390/md17020089.
Two new alkaloids indolepyrazines A () and B () were isolated from the marine-derived sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Indolepyrazine A represents the first example of alkaloids with an indole-pyrazine-oxindole skeleton. Both and showed antimicrobial activities against methicillin-resistant , , and with minimum inhibitory concentration (MIC) values of 12 μg/mL, 8⁻10 μg/mL, and 12⁻14 μg/mL, respectively.
从海洋来源的 sp. ZZ1275 中分离得到两个新的吲哚吡嗪生物碱 A()和 B()。通过广泛的核磁共振 (NMR) 光谱分析、高分辨率电喷雾电离质谱 (HRESIMS) 数据和电子圆二色性 (ECD) 计算，确定了它们的结构。吲哚吡嗪 A 代表了具有吲哚-吡嗪-氧吲哚骨架的生物碱的第一个例子。和均表现出抗耐甲氧西林的、和的活性，最小抑菌浓度 (MIC) 值分别为 12μg/mL、8-10μg/mL 和 12-14μg/mL。
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