简要综述：骨骼肌作为间充质基质细胞的输送途径
Concise Review: Skeletal Muscle as a Delivery Route for Mesenchymal Stromal Cells.
机构信息
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.
Faculty of Dentistry, University of Toronto, Toronto, Canada.
出版信息
Stem Cells Transl Med. 2019 May;8(5):456-465. doi: 10.1002/sctm.18-0208. Epub 2019 Feb 5.
Abstract
Mesenchymal stromal cells (MSCs) have demonstrated extensive capacity to modulate a catabolic microenvironment toward tissue repair. The fate, biodistribution, and dwell time of the in vivo delivered MSCs largely depend on the choice of the cell delivery route. Intramuscular (IM) delivery of MSCs is clinically safe and has been used for the effective treatment of local pathologies. Recent findings have shown that the secretome of the IM-delivered MSCs enters the circulation and provides systemic effects on distant organs. In addition, muscle tissue provides a safe residence for the delivered MSCs and an extended secretorily active dwell time compared with other delivery routes. There are, however, controversies concerning the fate of MSCs post IM-delivery and, specifically, into an injured site with proinflammatory cues. This review seeks to provide a brief overview of the fate and efficacy of IM-delivered MSCs and to identify the gaps that require further assessment for adoption of this promising route in the treatment of systemic disease. Stem Cells Translational Medicine 2019;8:456-465.
摘要
间充质基质细胞（MSCs）已被证明具有广泛的能力来调节分解代谢微环境以促进组织修复。体内传递的 MSCs 的命运、生物分布和停留时间在很大程度上取决于细胞传递途径的选择。MSCs 的肌肉内（IM）传递在临床上是安全的，并已被用于有效治疗局部病变。最近的研究结果表明，IM 传递的 MSCs 的分泌组进入循环，并对远处器官产生全身效应。此外，与其他传递途径相比，肌肉组织为传递的 MSCs 提供了安全的居留地和延长的分泌活性停留时间。然而，关于 IM 传递后 MSCs 的命运，特别是在有促炎信号的受伤部位的命运，存在争议。本综述旨在简要概述 IM 传递的 MSCs 的命运和功效，并确定需要进一步评估的空白点，以采用这种有前途的途径治疗全身性疾病。《干细胞转化医学》2019 年；8:456-465.
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