Piquero Martín J, Rothe de Arocha J, Beniamini Loker D
Instituto de Biomedicina, Caracas, Venezuela.
Med Cutan Ibero Lat Am. 1988;16(6):511-4.
A comparative double-blind study was carried out on sixty patients received oral contraceptives. Patients were treated with 20% azelaic acid or 4% hydroquinone. They were observed for 24 weeks and the results compared and checked for side effects. The results showed that the azelaic acid was not better than the hydroquinone in the treatment of melasma but it could be used as alternative drug.
对60名服用口服避孕药的患者进行了一项双盲对照研究。患者分别接受20%壬二酸或4%氢醌治疗。观察24周,并对结果进行比较和副作用检查。结果表明,壬二酸在治疗黄褐斑方面并不比氢醌好,但可作为替代药物使用。