发现和异源生物合成伯内特霉素酸：来自澳大利亚真菌 Burnetticillus aspergillus 的罕见 PKS-NRPS 衍生的两性吡咯里西啶二酮
Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii.
机构信息
School of Molecular Sciences , The University of Western Australia , Perth , Western Australia 6009 , Australia.
Microbial Screening Technologies Pty. Ltd. , Smithfield , New South Wales 2164 , Australia.
出版信息
Org Lett. 2019 Mar 1;21(5):1287-1291. doi: 10.1021/acs.orglett.8b04042. Epub 2019 Feb 8.
The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.
burnettramic 酸是一种新型抗生素，来自澳大利亚真菌 Aspergillus burnettii。这种罕见的两性 bolaamphiphilic 支架由β-d-甘露糖通过 26 个碳原子的链连接到吡咯里西啶二酮单元上。最丰富的代谢产物显示出很强的体外抗真菌活性。比较基因组学鉴定了杂种 PKS-NRPS bua 基因簇，这在 Aspergillus nidulans 中通过异源途径重建得到了验证。
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