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Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling.
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Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.
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Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes.
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BRAF augments WNT signaling in colorectal cancer via aberrant DNA methylation.
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本文引用的文献

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DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.
Cancer Cell. 2018 Feb 12;33(2):309-321.e5. doi: 10.1016/j.ccell.2018.01.008.
2
Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer.
Cell Rep. 2017 Dec 26;21(13):3833-3845. doi: 10.1016/j.celrep.2017.11.104.
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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.
Science. 2017 Oct 13;358(6360):234-238. doi: 10.1126/science.aao3130. Epub 2017 Sep 14.
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Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.
Cell Metab. 2017 Apr 4;25(4):954-960.e6. doi: 10.1016/j.cmet.2017.03.016.
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Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system.
Br J Cancer. 2017 Apr 11;116(8):1012-1020. doi: 10.1038/bjc.2017.52. Epub 2017 Mar 9.
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Correlation of an epigenetic mitotic clock with cancer risk.
Genome Biol. 2016 Oct 3;17(1):205. doi: 10.1186/s13059-016-1064-3.
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Organoids: Modeling Development and the Stem Cell Niche in a Dish.
Dev Cell. 2016 Sep 26;38(6):590-600. doi: 10.1016/j.devcel.2016.08.014.

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