IFITM1是卵巢和生殖器外子宫内膜异位症中子宫内膜间质细胞的一种新型高敏标志物。

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis.

作者信息

Sun Hui, Fukuda Shinya, Hirata Tetsuya, Arakawa Tomoko, Ma Suke, Neriishi Kazuaki, Wang Yu, Takeuchi Arisa, Saeki Ai, Harada Miyuki, Hirota Yasushi, Matsumoto Takashi, Koga Kaori, Wada-Hiraike Osamu, Kurihara Masatoshi, Fujii Tomoyuki, Osuga Yutaka

机构信息

1 Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan.

2 Department of Gynecology, Osaka Central Hospital, Osaka, Japan.

出版信息

Reprod Sci. 2019 Feb 21:1933719119831782. doi: 10.1177/1933719119831782.

DOI:10.1177/1933719119831782

PMID:30791812

Abstract

When the presence of endometriotic lesions are not evident by hematoxylin and eosin staining, CD10 is used to highlight and confirm the presence of endometriotic stroma. However, CD10 is not specific only to the endometrial stroma but is also expressed in many other cells. Recently, interferon-inducible transmembrane protein 1 (IFITM1) was reported as a highly specific immunohistochemical marker of normal endometrial stroma and endometrial stromal neoplasm. In this study, we examined the expression of IFITM1 and CD10 in 18 cases of ovarian endometriosis and 44 cases of extragenital endometriosis. Among the 62 patients, 62 (100.0%) were positive for IFITM1 and 60 (96.8%) for CD10, and CD10 was negative in 2 cases that were positive for IFITM1. Additionally, we found that IFITM1 sensitivity was unaffected by the presence or absence of hormonal therapy. To the best of our knowledge, this represents the first demonstration of IFITM1 as a highly sensitive stromal marker of ovarian and extragenital endometriosis.

摘要

当苏木精-伊红染色无法明显显示子宫内膜异位症病灶的存在时，CD10可用于突出显示并确认子宫内膜异位症间质的存在。然而，CD10并非仅特异性地表达于子宫内膜间质，在许多其他细胞中也有表达。最近，干扰素诱导跨膜蛋白1（IFITM1）被报道为正常子宫内膜间质和子宫内膜间质肿瘤的一种高度特异性免疫组化标志物。在本研究中，我们检测了18例卵巢子宫内膜异位症和44例生殖器外子宫内膜异位症中IFITM1和CD10的表达。在这62例患者中，62例（100.0%）IFITM1呈阳性，60例（96.8%）CD10呈阳性，2例IFITM1阳性的病例中CD10呈阴性。此外，我们发现IFITM1的敏感性不受激素治疗与否的影响。据我们所知，这是首次证明IFITM1是卵巢和生殖器外子宫内膜异位症的一种高度敏感的间质标志物。