以紫杉烷为基础的化疗成功治疗晚期皮脂腺癌：一例报告及文献综述
Successful Treatment with Taxane-Based Chemotherapy in Advanced Sebaceous Carcinoma: A Case Report and Literature Review.
作者信息
Ota Shuji, Sakamoto Takahiko, Ochiai Ryosuke, Haruyama Terunobu, Ishihara Masashi, Natsume Maika, Fukasawa Yoko, Tanzawa Shigeru, Usui Ryo, Honda Takeshi, Ichikawa Yasuko, Watanabe Kiyotaka, Sasajima Yuko, Mizota Atsushi, Seki Nobuhiko
机构信息
Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.
出版信息
Case Rep Oncol. 2019 Jan 11;12(1):47-52. doi: 10.1159/000493850. eCollection 2019 Jan-Apr.
For sebaceous carcinoma (SC), a rare malignant tumor, no standard chemotherapy regimen for patients with distant metastasis has been studied. We experienced a case of eyelid SC with multiple lung metastases that responded to combination chemotherapy with carboplatin and paclitaxel with 11-month progression-free survival (PFS). This patient also responded to second-line treatment with docetaxel, another taxane, with 7-month PFS, resulting in at least 18 months of survival at the time of reporting. This report shows that taxane-based chemotherapy may be effective for advanced SC, for which no standard therapy has been established.
对于皮脂腺癌（SC）这种罕见的恶性肿瘤，尚未对远处转移患者的标准化疗方案进行研究。我们遇到一例眼睑皮脂腺癌伴多发肺转移的病例，该病例对卡铂和紫杉醇联合化疗有反应，无进展生存期（PFS）为11个月。该患者对二线治疗多西他赛（另一种紫杉烷类药物）也有反应，PFS为7个月，在报告时生存期至少为18个月。本报告表明，基于紫杉烷类的化疗可能对晚期皮脂腺癌有效，而晚期皮脂腺癌尚无标准治疗方案。
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