炎性饮食模式与女性银屑病、银屑病关节炎和特应性皮炎的发病风险：一项队列研究。
Inflammatory dietary pattern and incident psoriasis, psoriatic arthritis, and atopic dermatitis in women: A cohort study.
机构信息
School of Medicine, Queen's University, Kingston, Canada.
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
出版信息
J Am Acad Dermatol. 2019 Jun;80(6):1682-1690. doi: 10.1016/j.jaad.2019.02.038. Epub 2019 Feb 21.
BACKGROUND
Diet is a modulator of inflammation that might impact inflammatory skin diseases.
OBJECTIVE
To assess the relationship between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD).
METHODS
We conducted cohort studies among women in the Nurses' Health Study II. The Empirical Dietary Inflammatory Pattern (EDIP) score was calculated at baseline and every 4 years. Incident psoriasis, PsA, and AD were assessed by validated self-report. We used multivariable-adjusted Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDIP quintiles and risk for psoriasis, PsA, and AD.
RESULTS
We had 85,185 participants in the psoriasis analysis and 63,443 in the AD analysis. There were 1432 cases of psoriasis, 262 cases of PsA, and 403 cases of AD. Pro-inflammatory dietary patterns were not associated with the risk for outcomes in multivariable models (all P values for trend >.05). HRs comparing the highest to the lowest EDIP quintile were 0.99 (95% CI 0.83-1.18) for psoriasis, 1.22 (95% CI 0.81-1.83) for PsA, and 0.96 (95% CI 0.69-1.34) for AD.
LIMITATIONS
Recall and self-report.
CONCLUSION
Our findings do not support dietary inflammatory potential as a risk factor for psoriasis, PsA, or AD.
背景
饮食是炎症的调节剂，可能会影响炎症性皮肤病。
目的
评估促炎饮食模式与银屑病、银屑病关节炎（PsA）和特应性皮炎（AD）发病之间的关系。
方法
我们在护士健康研究 II 中进行了队列研究。在基线和每 4 年计算一次经验性饮食炎症模式（EDIP）评分。通过验证的自我报告评估银屑病、PsA 和 AD 的发病情况。我们使用多变量调整的 Cox 比例风险模型来计算 EDIP 五分位数与银屑病、PsA 和 AD 风险之间的风险比（HR）和 95%置信区间（CI）。
结果
我们对银屑病分析有 85185 名参与者，对 AD 分析有 63443 名参与者。有 1432 例银屑病、262 例 PsA 和 403 例 AD。在多变量模型中，促炎饮食模式与结局风险无关（所有趋势 P 值>.05）。与 EDIP 五分位数最低组相比，最高组的 HR 分别为银屑病 0.99（95%CI 0.83-1.18）、PsA 1.22（95%CI 0.81-1.83）和 AD 0.96（95%CI 0.69-1.34）。
局限性
回忆和自我报告。
结论
我们的研究结果不支持饮食炎症潜能作为银屑病、PsA 或 AD 的危险因素。
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