Washington University School of Medicine, St. Louis, MO, USA.
Stanford University School of Medicine, Stanford, CA, USA.
J Clin Epidemiol. 2019 Jun;110:74-81. doi: 10.1016/j.jclinepi.2019.02.011. Epub 2019 Feb 28.
To provide recommendations for the selection of comparators for randomized controlled trials of health-related behavioral interventions.
The National Institutes of Health Office of Behavioral and Social Science Research convened an expert panel to critically review the literature on control or comparison groups for behavioral trials and to develop strategies for improving comparator choices and for resolving controversies and disagreements about comparators.
The panel developed a Pragmatic Model for Comparator Selection in Health-Related Behavioral Trials. The model indicates that the optimal comparator is the one that best serves the primary purpose of the trial but that the optimal comparator's limitations and barriers to its use must also be taken into account.
We developed best practice recommendations for the selection of comparators for health-related behavioral trials. Use of the Pragmatic Model for Comparator Selection in Health-Related Behavioral Trials can improve the comparator selection process and help resolve disagreements about comparator choices.
为健康相关行为干预的随机对照试验选择对照物提供建议。
美国国立卫生研究院行为和社会科学研究办公室召集了一个专家小组,对行为试验的对照或对照组文献进行了批判性审查,并制定了改善对照物选择的策略,以及解决关于对照物的争议和分歧的策略。
该小组制定了健康相关行为试验中对照物选择的实用模型。该模型表明,最佳对照物是最能满足试验主要目的的对照物,但也必须考虑到最佳对照物的局限性和使用障碍。
我们为健康相关行为试验中对照物的选择制定了最佳实践建议。使用健康相关行为试验中的对照物选择实用模型可以改进对照物选择过程,并有助于解决关于对照物选择的分歧。