Striatal and mesolimbic dopaminergic contribution to 3,4-dihydroxyphenylacetic acid sulfate in rat plasma.
作者信息
Boudet C, Simon H, Cottet-Emard J M, Dalmaz Y, Peyrin L
出版信息
Eur J Pharmacol. 1986 Feb 11;121(1):113-8. doi: 10.1016/0014-2999(86)90399-7.
PMID:3082654
Abstract
Free and sulfated 3,4-dihydroxyphenylacetic acid (DOPAC) were measured in rat plasma after bilateral 6-hydroxydopamine lesions of striatum or mesolimbic tissue (nucleus accumbens + olfactory tubercle). Both lesions selectively reduced plasma DOPAC sulfate levels without altering free DOPAC or catecholamine levels in plasma, sympathetic ganglia or adrenal medulla. The present work confirms our previous findings and suggests that DOPAC sulfate functional state of striatal and mesolimbic dopaminergic neurons.
摘要
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