子宫内膜异位症中的抗炎细胞因子。
Anti-inflammatory cytokines in endometriosis.
机构信息
Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200090, People's Republic of China.
Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 200040, China.
出版信息
Cell Mol Life Sci. 2019 Jun;76(11):2111-2132. doi: 10.1007/s00018-019-03056-x. Epub 2019 Mar 2.
Although the pathogenesis of endometriosis is not fully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g., interleukin-4 and -10, and transforming growth factor-β1) occurs in women with endometriosis, including in serum, peritoneal fluid and ectopic lesions. These anti-inflammatory cytokines also have indispensable roles in the progression of endometriosis, including by promoting survival, growth, invasion, differentiation, angiogenesis, and immune escape of the endometriotic lesions. In this review, we provide an overview of the expression, origin, function and regulation of anti-inflammatory cytokines in endometriosis, with brief discussion and perspectives on their future clinical implications in the diagnosis and therapy of the disease.
虽然子宫内膜异位症的发病机制尚未完全阐明，但它通常被认为是一种炎症性疾病。越来越多的研究表明，子宫内膜异位症患者存在抗炎细胞因子（如白细胞介素-4 和白细胞介素-10、转化生长因子-β1）的差异表达，包括在血清、腹腔液和异位病灶中。这些抗炎细胞因子在子宫内膜异位症的进展中也具有不可或缺的作用，包括促进子宫内膜异位病灶的存活、生长、侵袭、分化、血管生成和免疫逃逸。在这篇综述中，我们概述了抗炎细胞因子在子宫内膜异位症中的表达、来源、功能和调节，并简要讨论和展望了它们在该疾病的诊断和治疗中的未来临床意义。
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