Geng Changran, Ai Yao, Tang Xiaobin, Shu Diyun, Gong Chunhui, Guan Fada
Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China.
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Nanjing, 210016, China.
Australas Phys Eng Sci Med. 2019 Jun;42(2):481-487. doi: 10.1007/s13246-019-00744-7. Epub 2019 Mar 4.
Cerenkov luminescence imaging (CLI) is an emerging optical imaging technique, which has been widely investigated for biological imaging. In this study, we proposed to integrate the CLI technique with the radionuclide treatment as a "see-and-treat" approach, and evaluated the performance of the pinhole collimator-based CLI technique. The detection of Cerenkov luminescence during radionuclide therapy was simulated using the Monte Carlo technique for breast cancer treatment as an example. Our results show that with the pinhole collimator-based configuration, the location, size and shape of the tumors can be clearly visualized on the Cerenkov luminescence images of the breast phantom. In addition, the CLI of multiple tumors can reflect the relative density of radioactivity among tumors, indicating that the intensity of Cerenkov luminescence is independent of the size and shape of a tumor. The current study has demonstrated the high-quality performance of the pinhole collimator-based CLI in breast tumor imaging for the "see-and-treat" multi-modality treatment.
切伦科夫发光成像（CLI）是一种新兴的光学成像技术，已被广泛用于生物成像研究。在本研究中，我们提议将CLI技术与放射性核素治疗相结合，作为一种“可视即治疗”的方法，并评估基于针孔准直器的CLI技术的性能。以乳腺癌治疗为例，使用蒙特卡罗技术模拟了放射性核素治疗期间切伦科夫发光的检测。我们的结果表明，基于针孔准直器的配置，可以在乳房模型的切伦科夫发光图像上清晰地看到肿瘤的位置、大小和形状。此外，多个肿瘤的CLI可以反映肿瘤之间放射性的相对密度，这表明切伦科夫发光的强度与肿瘤的大小和形状无关。当前的研究已经证明了基于针孔准直器的CLI在乳腺癌成像用于“可视即治疗”多模态治疗方面的高质量性能。
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