出生时的身体大小、婴儿期的生长以及更年期和自然绝经的时间。
Body size at birth, early-life growth and the timing of the menopausal transition and natural menopause.
机构信息
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA; School of Health Sciences, Walden University, Minneapolis, MN, USA.
出版信息
Reprod Toxicol. 2020 Mar;92:91-97. doi: 10.1016/j.reprotox.2019.02.013. Epub 2019 Mar 1.
BACKGROUND
Whether birth weight and early-life growth are associated with age at menopause has not been resolved.
METHODS
We conducted a prospective study in two U.S. birth cohorts to investigate the relation of weight at birth and weight and growth trajectory through age 4 years to menstrual status among 1001 women ages 39-49 years. We used logistic regression models with GEE.
RESULTS
Women who weighed more at birth and at one year were less likely to have experienced the menopausal transition or natural menopause by age 39-49 years (odds ratio(OR) = 0.50, 95% confidence interval(CI) = 0.32, 0.77 and OR = 0.82, 95%CI = 0.68, 0.99 per kilogram increase at birth and age one, respectively).
CONCLUSIONS
Women who had a lighter weight at birth and women who were lighter than their peers through infancy experienced the menopausal transition or natural menopause at an earlier age.
背景
出生体重和儿童早期生长与绝经年龄之间的关系尚未明确。
方法
我们在美国的两个出生队列中进行了一项前瞻性研究，以调查出生体重以及出生后至 4 岁时的体重和生长轨迹与 1001 名年龄在 39-49 岁的女性的月经状况之间的关系。我们使用具有广义估计方程（GEE）的逻辑回归模型进行分析。
结果
出生时和 1 岁时体重较重的女性在 39-49 岁时经历更年期或自然绝经的可能性较小（比值比（OR）=0.50，95%置信区间（CI）=0.32，0.77 和 OR=0.82，95%CI=0.68，0.99 分别每千克出生时和 1 岁时的体重增加）。
结论
出生体重较轻的女性和在婴儿期体重比同龄人轻的女性更早经历更年期或自然绝经。
Zotero 插件