抑郁症与载脂蛋白E ε4等位基因多态性相关：一项荟萃分析。
Depression was associated with apolipoprotein E ε4 allele polymorphism: A meta-analysis.
作者信息
Wang Wei-Wei, Liu Xiao-Lei, Ruan Ye, Wang Lin, Bao Tian-Hao
机构信息
The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China.
The First Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, PR China.
出版信息
Iran J Basic Med Sci. 2019 Feb;22(2):112-117. doi: 10.22038/ijbms.2018.30825.7436.
OBJECTIVES
Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies.
MATERIALS AND METHODS
Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment and implementation of inclusion/exclusion criteria. This meta-analysis was performed using Review Manager 5.2 software. The odds ratios (ORs) with corresponding 95% confidence interval (CIs) were calculated using a fixed effects model. Funnel plots and Egger's regression tests were used to assess the publication bias.
RESULTS
A total of nine studies that met the inclusion criteria were identified by performing a comprehensive search on the association between APOE polymorphisms and depression. ε4 allele was significantly associated with depression (allele: OR=1.36, 95%CI=1.11-1.66, =0.003; dominant: OR=1.34, 95%CI=1.06-1.68, =0.001; recessive: OR= 1.11, 95%CI =0.45-2.76, P=0.82). HAMD scores were higher in depression patients with- ε4 genotype than who without- ε4 genotype (OR=0.96, 95%CI=0.16-1.76, =0.02).
CONCLUSION
ε4 allele increased the depression risk; depressive patients carrying ε4 allele had more severe depressive symptoms.
目的
既往研究对于载脂蛋白E（APOE）基因多态性与抑郁症之间的关联得出了不同结论。本荟萃分析旨在澄清这些争议。
材料与方法
通过检索国内外数据库来识别文献。通过质量评估和纳入/排除标准的实施来确定符合荟萃分析条件的文章。本荟萃分析使用Review Manager 5.2软件进行。采用固定效应模型计算比值比（OR）及其相应的95%置信区间（CI）。采用漏斗图和Egger回归检验评估发表偏倚。
结果
通过对APOE基因多态性与抑郁症之间的关联进行全面检索，共识别出9项符合纳入标准的研究。ε4等位基因与抑郁症显著相关（等位基因：OR = 1.36，95%CI = 1.11 - 1.66，P = 0.003；显性：OR = 1.34，95%CI = 1.06 - 1.68，P = 0.001；隐性：OR = 1.11，95%CI = 0.45 - 2.76，P = 0.82）。ε4基因型的抑郁症患者的汉密尔顿抑郁量表（HAMD）评分高于非ε4基因型患者（OR = 0.96，95%CI = 0.16 - 1.76，P = 0.02）。
结论
ε4等位基因增加了抑郁症风险；携带ε4等位基因的抑郁症患者有更严重的抑郁症状。
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