将治疗药物递送至内耳：血迷路屏障的挑战。
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier.
机构信息
Biological Sciences, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
出版信息
Sci Transl Med. 2019 Mar 6;11(482). doi: 10.1126/scitranslmed.aao0935.
Abstract
Permanent hearing loss affects more than 5% of the world's population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the cochlea and vestibular system of the inner ear is complicated by their inaccessible location. Drug delivery to the inner ear via the vasculature is an attractive noninvasive strategy, yet the blood-labyrinth barrier at the luminal surface of inner ear capillaries restricts entry of most blood-borne compounds into inner ear tissues. Here, we compare the blood-labyrinth barrier to the blood-brain barrier, discuss invasive intratympanic and intracochlear drug delivery methods, and evaluate noninvasive strategies for drug delivery to the inner ear.
摘要
永久性听力损失影响了全球超过 5%的人口，但目前尚无能够保护或恢复听力的非器械疗法。由于内耳耳蜗和前庭系统的位置难以到达，因此向其输送治疗药物的过程较为复杂。通过血管向内耳输送药物是一种很有吸引力的非侵入性策略，但内耳道毛细血管的腔面血迷路屏障限制了大多数血源性化合物进入内耳组织。在这里，我们将血迷路屏障与血脑屏障进行了比较，讨论了侵入性鼓室内和耳蜗内药物输送方法，并评估了向内耳输送药物的非侵入性策略。
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