用于微波医学成像应用的肌肉和脂肪组织模拟溶液的介电特性。

Dielectric properties of muscle and adipose tissue-mimicking solutions for microwave medical imaging applications.

机构信息

Faculty of Science, Department of Physics, University of Malta, Msida, MSD 2080, Malta. Author to whom any correspondence should be addressed.

出版信息

Phys Med Biol. 2019 Apr 30;64(9):095009. doi: 10.1088/1361-6560/ab0dda.

DOI:10.1088/1361-6560/ab0dda

PMID:30844769

Abstract

The aim of the present study was to synthesize mixture solutions which can accurately mimic the dielectric properties of biological tissues, specifically muscle and adipose tissues between 500 MHz and 50 GHz. Mixtures utilizing concentrations of bovine serum albumin (BSA) dissolved in phosphate buffered saline (PBS) and Ringer's solutions were synthesized to mimic in vivo and ex vivo muscle tissues. Solutions consisting of concentrations of peanut oil and Triton X-100 (TX) in PBS and Ringer's solutions were also synthesized to mimic in vivo and ex vivo adipose tissue. Results were then analysed and compared to measured dielectric properties of in vivo and ex vivo biological tissues from another previous study. Good agreement with said dielectric property measurements were obtained since the solutions from this study yielded low RMSE and RMSRE values. This implied that such solutions can be utilized in the construction of human body phantoms for narrowband and ultra-wideband microwave devices for near field breast cancer imaging.

摘要

本研究旨在合成混合溶液，以准确模拟生物组织（特别是肌肉和脂肪组织）在 500MHz 至 50GHz 频率范围内的介电特性。利用牛血清白蛋白（BSA）在磷酸盐缓冲盐水（PBS）和林格氏溶液中的浓度合成混合物，以模拟体内和离体肌肉组织。还合成了含有花生油和 Triton X-100（TX）在 PBS 和林格氏溶液中浓度的溶液，以模拟体内和离体脂肪组织。然后对结果进行分析，并与另一个先前研究中测量的体内和离体生物组织的介电特性进行比较。由于本研究中的溶液产生的 RMSE 和 RMSRE 值较低，因此与所述介电特性测量值吻合良好。这意味着此类溶液可用于构建人体模型，用于近场乳腺癌成像的窄带和超宽带微波设备。