Core Technology Laboratories, Asahi Group Holdings, Ltd., 1-21, Midori 1-Chome, Moriya-shi 302-0106, Japan.
Nutrients. 2019 Mar 6;11(3):564. doi: 10.3390/nu11030564.
We determined the serum uric acid-lowering effects of combined daily supplementation of glycine and tryptophan in patients with mild hyperuricemia using a randomized, double-blind, placebo-controlled, crossover clinical trial design. Japanese healthy adult males and females with mild hyperuricemia (fasting serum uric acid of 6.6⁻7.9 mg/dL) ingested a powder mixture containing 3.0 g of glycine and 0.2 g of tryptophan or a placebo powder once daily at bedtime for 6 weeks. Combined supplementation with glycine and tryptophan significantly decreased serum uric acid levels (from 7.1 mg/dL to 6.7 mg/dL, = 0.004) before and after the trial. Serum uric acid concentrations significantly decreased in the subjects supplemented with the amino acid mixture compared with those in placebo-treated subjects ( = 0.028). In addition, the combination treatment with glycine and tryptophan decreased serum triglyceride levels (from 119 mg/dL to 86 mg/dL, = 0.002). Increased solubility of uric acid caused by urinary pH were likely contributors to the serum uric acid-lowering effects of the amino acid mixture.
我们采用随机、双盲、安慰剂对照、交叉临床试验设计，确定了甘氨酸和色氨酸联合日补充对轻度高尿酸血症患者血清尿酸降低的效果。日本健康的轻中度高尿酸血症成年男女（空腹血清尿酸 6.6⁻7.9mg/dL）每晚睡前口服含 3.0g 甘氨酸和 0.2g 色氨酸的粉末混合物或安慰剂粉末一次，持续 6 周。甘氨酸和色氨酸联合补充可显著降低试验前后的血清尿酸水平（从 7.1mg/dL 降至 6.7mg/dL， = 0.004）。与安慰剂治疗组相比，补充氨基酸混合物的受试者血清尿酸浓度显著降低（ = 0.028）。此外，甘氨酸和色氨酸联合治疗可降低血清甘油三酯水平（从 119mg/dL 降至 86mg/dL， = 0.002）。尿酸溶解度的增加导致尿液 pH 值升高，可能是氨基酸混合物降低血清尿酸的作用机制之一。
