新型抗 CD38 抗体的作用机制：增强骨髓瘤免疫疗法。
Mechanism of Action of a New Anti-CD38 Antibody: Enhancing Myeloma Immunotherapy.
机构信息
Department of Medical Science, University of Torino, Torino, Italy.
MD/PhD Special Program, School of Medicine, University of Torino, Torino, Italy.
出版信息
Clin Cancer Res. 2019 May 15;25(10):2946-2948. doi: 10.1158/1078-0432.CCR-19-0260. Epub 2019 Mar 7.
Abstract
Antibody therapy is a treatment option for several diseases, including multiple myeloma. The logic behind it is relatively simple: A target molecule is selected because of its expression on tumor cells, and the antibody delivers cytotoxic effects. Therapeutic results in multiple myeloma indicate that the anti-CD38 antibodies may have relevant immunotherapeutic properties..
摘要
抗体疗法是多种疾病（包括多发性骨髓瘤）的一种治疗选择。其背后的逻辑相对简单：由于靶分子在肿瘤细胞上的表达，选择一个靶分子，然后抗体传递细胞毒性作用。多发性骨髓瘤的治疗结果表明，抗 CD38 抗体可能具有相关的免疫治疗特性。
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