室外空气污染与妊娠期糖尿病：一项系统评价和荟萃分析
Outdoor Air Pollution and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.
作者信息
Elshahidi Mohamed H
机构信息
Faculty of Medicine, Mansoura University, Mansoura, Dakahliya, Egypt.
出版信息
Iran J Public Health. 2019 Jan;48(1):9-19.
BACKGROUND
During the past 20 years, the prevalence of gestational diabetes mellitus (GDM) has increased by ∼10%-100% in several race/ethnicity groups. There is an association between ambient air pollution (AAP) and GDM. This study aimed to ummarize the evidence about the association between AAP and GDM.
METHODS
PubMed, Embase, Scopus, Web of Science and Cochrane Library were searched from inception till Oct 2017. Studies about the association between ambient air pollutants levels and GDM were included. Pooled effect estimates and their 95% confidence interval (CI) were calculated using .
RESULTS
Eight studies met the inclusion criteria. The odds of developing GDM upon exposure to CO (per 1 ppm), NO (per 1 ppb), NO2 (per 10 μg/m3), NOx (per 1 ppb), O3 (per 10 ppb), SO2 (per 10 ppb), PM10 (per 10 μg/m3) and PM2.5 (per 10 μg/m3) were 1.47 (95% CI 0.88-2.06), 1.04 (95% CI 1.03-1.06), 1 (95% CI 0.93-1.08), 1.02 (95% CI 1-1.04), 1.05 (95% CI 0.94-1.16), 1.39 (95% CI 1.04-1.73), 0.97 (95% CI 0.94-0.99) and 1.12 (95% CI 0.93-1.31), respectively.
CONCLUSION
The current literature showed evidence for an association between AAP and GDM. However, further well-designed studies are needed.
背景
在过去20年中，几个种族/族裔群体的妊娠期糖尿病（GDM）患病率增加了约10% - 100%。环境空气污染（AAP）与GDM之间存在关联。本研究旨在总结有关AAP与GDM之间关联的证据。
方法
检索了从创刊至2017年10月的PubMed、Embase、Scopus、Web of Science和Cochrane图书馆。纳入了关于环境空气污染物水平与GDM之间关联的研究。使用……计算合并效应估计值及其95%置信区间（CI）。
结果
八项研究符合纳入标准。暴露于一氧化碳（每1 ppm）、一氧化氮（每1 ppb）、二氧化氮（每10 μg/m³）、氮氧化物（每1 ppb）、臭氧（每10 ppb）、二氧化硫（每10 ppb）、可吸入颗粒物（PM10，每10 μg/m³）和细颗粒物（PM2.5，每10 μg/m³）后患GDM的比值分别为1.47（95% CI 0.88 - 2.06）、1.04（95% CI 1.03 - 1.06）、1（95% CI 0.93 - 1.08）、1.02（95% CI 1 - 1.04）、1.05（95% CI 0.94 - 1.16）、1.39（95% CI 1.04 - 1.73）以及0.97（95% CI 0.94 - 0.99）和1.12（95% CI 0.93 - 1.31）。
结论
当前文献表明AAP与GDM之间存在关联的证据。然而，需要进一步设计良好的研究。
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