Synthetic Biology Group, MRC London Institute of Medical Sciences, London, UK.
Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Curr Genet. 2019 Aug;65(4):877-882. doi: 10.1007/s00294-019-00951-5. Epub 2019 Mar 8.
Despite being widely used in reporter technologies, bioluminescent systems are largely understudied. Of at least forty different bioluminescent systems thought to exist in nature, molecular components of only seven light-emitting reactions are known, and the full biochemical pathway leading to light emission is only understood for two of them. Here, we provide a succinct overview of currently known bioluminescent systems highlighting available tools for research and discussing future applications.
尽管生物发光系统在报道技术中被广泛应用,但它们在很大程度上仍未得到充分研究。在自然界中,至少存在四十种不同的生物发光系统,但目前已知的发光反应的分子组成只有七种,而对于其中的两种,人们才刚刚了解其导致发光的完整生化途径。在这里,我们提供了对当前已知生物发光系统的简洁概述,重点介绍了可用于研究的现有工具,并讨论了未来的应用。