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[1991 - 2017年四川省艾滋病病毒/艾滋病感染者生存分析]

[Survival analysis of people living with HIV/AIDS in Sichuan province, 1991-2017].

作者信息

Zeng Y L, Tang H L, Li J M, Wang Q S, Yu H, Su L, Yang W, Gong Y, Li T, Huang W L, Zhang L L, Lai W W

机构信息

Department of AIDS/STD Control and Prevention, Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China.

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Mar 10;40(3):309-314. doi: 10.3760/cma.j.issn.0254-6450.2019.03.010.

Abstract

To analyze the survival time of people living with HIV/AIDS and related influencing factors in Sichuan province during 1991-2017. A retrospective cohort study was conducted to analyze the data of 143 988 HIV/AIDS cases. The data were collected from Chinese HIV/AIDS Comprehensive Information Management System. Life table method was used to calculate the survival proportion of the cases, and Cox proportion hazard regression model was used to identify the factors related with survival time. Among 143 988 HIV/AIDS cases a total of 30 420 cases died of AIDS related diseases (21.1) and the average survival time was 11.51 years (95: 11.39-11.64). Multivariate Cox regression analysis showed that the influencing factors for the survival of HIV/AIDS cases were gender (male . female, =1.35, 95: 1.32-1.40), education level (primary school or below . junior middle school: =1.15, 95: 1.12-1.18), ethnic group (Han . other ethnic groups, =1.46, 95: 1.41-1.52), occupation (farmer . other occupations: =1.26, 95: 1.22-1.29), age (≥55 years old . 15-24 years old: =3.18, 95: 3.02- 3.36), disease phase (AIDS . HIV infection: =1.44, 95: 1.39-1.48), antiretroviral therapy (ART) (receiving ART receiving no ART: =0.20, 95: 0.19-0.20), and CD(4)(+)T cell counts at diagnosis (>500 cells/μl .<200 cells/μl: =0.42, 95: 0.40-0.45). The average survival time of HIV/AIDS cases was 11.51 years in Sichuan during 1991- 2017. The risk factors for the survival of the cases were male, education level of primary school or below, Han ethnic group, farmer, old age at diagnosis, disease phase, The protective factors for the survival of HIV/AIDS cases were receiving ART and higher CD(4)(+) T cell counts at diagnosis.

摘要

分析1991 - 2017年四川省艾滋病病毒/艾滋病(HIV/AIDS)感染者的生存时间及相关影响因素。开展一项回顾性队列研究,分析143988例HIV/AIDS病例的数据。数据来源于中国HIV/AIDS综合信息管理系统。采用寿命表法计算病例的生存比例,并用Cox比例风险回归模型识别与生存时间相关的因素。在143988例HIV/AIDS病例中,共有30420例死于艾滋病相关疾病(21.1%),平均生存时间为11.51年(95%置信区间:11.39 - 11.64年)。多因素Cox回归分析显示,HIV/AIDS病例生存的影响因素有性别(男性.女性,比值比 =1.35,95%置信区间:1.32 - 1.40)、文化程度(小学及以下.初中,比值比 =1.15,95%置信区间:1.12 - 1.18)、民族(汉族.其他民族,比值比 =1.46,95%置信区间:1.41 - 1.52)、职业(农民.其他职业,比值比 =1.26,95%置信区间:1.22 - 1.29)、年龄(≥55岁.15 - 24岁,比值比 =3.18,95%置信区间:3.02 - 3.36)、疾病阶段(艾滋病. HIV感染,比值比 =1.44,95%置信区间:1.39 - 1.48)、抗逆转录病毒治疗(ART)(接受ART.未接受ART,比值比 =0.20,95%置信区间:0.19 - 0.20)以及诊断时的CD4(+)T细胞计数(>500个细胞/μl.<200个细胞/μl,比值比 =0.42,95%置信区间:0.40 - 0.45)。1991 - 2017年四川省HIV/AIDS病例的平均生存时间为11.51年。病例生存的危险因素为男性、小学及以下文化程度、汉族、农民、诊断时年龄较大、疾病阶段;HIV/AIDS病例生存的保护因素为接受ART以及诊断时较高的CD4(+)T细胞计数。

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