Howlett Sarah, Sullivan Tadhg, Abdolrasouli Alireza, Borman Andrew M, Johnson Elizabeth M, Lewis Paul, Baheerathan Aravindhan, Davies Frances, Sanderson Frances, Davies Nicholas, Singh-Curry Victoria
Department of Neurology, Charing Cross Hospital, Imperial College NHS Trust, London W6 8RF, UK.
Department of Medical Microbiology, North West London Pathology, Imperial College Healthcare NHS Trust, London W6 8RF, UK.
Med Mycol Case Rep. 2019 Feb 28;24:23-26. doi: 10.1016/j.mmcr.2019.02.004. eCollection 2019 Jun.
Cladophialophora bantiana is a neurotropic mould and primary cause of cerebral phaeohyphomycoses, which presents with brain abscesses in both immunocompromised and immunocompetent individuals. It is associated with high mortality due to delay in diagnosis and absence of standardised therapy. We present a case of fatal cerebral phaeohyphomycosis in a 67-year-old Caucasian man. Diagnosis was achieved by histopathological examination of brain tissue followed by conventional culture and molecular identification. We highlight diagnostic and treatment challenges involved.
班替枝孢霉是一种嗜神经霉菌，是脑暗色丝孢霉病的主要病因，在免疫功能低下和免疫功能正常的个体中均可引起脑脓肿。由于诊断延迟和缺乏标准化治疗，其死亡率很高。我们报告一例67岁白种男性致命性脑暗色丝孢霉病的病例。通过脑组织的组织病理学检查、传统培养和分子鉴定得以确诊。我们强调了其中涉及的诊断和治疗挑战。
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