Li Zhuo, Zhu Hua, Zhang Ling, Qin Chuan
Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences & Comparative Medical Center Peking Union Medical College Beijing China.
Animal Model Exp Med. 2018 Sep 25;1(3):180-188. doi: 10.1002/ame2.12033. eCollection 2018 Sep.
Alzheimer's disease (AD) is an increasingly common neurodegenerative disease. Since the intestinal microbiome is closely related to nervous system diseases, alterations in the composition of intestinal microbiota could potentially contribute to the pathophysiology of AD. However, how the initial interactions with intestinal microbes alter events later in life, such as during neurodegenerative diseases, is still unclear. This review summarizes what is known about the relationship between the intestinal microbiome and AD.
阿尔茨海默病(AD)是一种日益常见的神经退行性疾病。由于肠道微生物群与神经系统疾病密切相关,肠道微生物群组成的改变可能会对AD的病理生理学产生影响。然而,与肠道微生物的初始相互作用如何改变生命后期的事件,如神经退行性疾病期间的事件,仍不清楚。这篇综述总结了关于肠道微生物群与AD之间关系的已知情况。