Laboratory of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan.
Department of Nephrology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Semin Immunopathol. 2019 May;41(3):283-297. doi: 10.1007/s00281-019-00733-8. Epub 2019 Mar 19.
IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and GM-CSF secreted by autoimmune Th17 cells has been shown to be effective for the treatment of the diseases. Understanding a molecular basis of Th17 differentiation and effector functions is therefore critical for the regulation of the pathogenicity of tissue Th17 cells in chronic inflammation. Here, we discuss the roles of proinflammatory cytokines and environmental stimuli in the control of Th17 differentiation and chronic tissue inflammation by pathogenic Th17 cells in humans and in mouse models of autoimmune diseases. We also highlight recent advances in the regulation of pathogenic Th17 cells by gut microbiota and immunometabolism in autoimmune arthritis.
白细胞介素-17 产生的辅助性 T 细胞（Th17 细胞）被认为与许多炎症和自身免疫性疾病的发病机制有关。靶向自身免疫性 Th17 细胞分泌的效应细胞因子白细胞介素-17 和粒细胞-巨噬细胞集落刺激因子已被证明对治疗这些疾病有效。因此，了解 Th17 细胞分化和效应功能的分子基础对于调节慢性炎症中组织 Th17 细胞的致病性至关重要。在这里，我们讨论了促炎细胞因子和环境刺激物在控制人类致病性 Th17 细胞和自身免疫性疾病小鼠模型中 Th17 细胞分化和慢性组织炎症中的作用。我们还强调了肠道微生物群和自身免疫性关节炎中的免疫代谢对致病性 Th17 细胞的调节的最新进展。
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