解析寨卡病毒蛋白对神经祖细胞的毒性作用。
Dissecting the Toxic Effects of Zika Virus Proteins on Neural Progenitor Cells.
机构信息
Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Neuron. 2019 Mar 20;101(6):989-991. doi: 10.1016/j.neuron.2019.03.009.
PMID:30897362
Abstract
The mechanisms by which Zika virus (ZIKV) disrupts neurogenesis and causes microcephaly are poorly understood. In this issue of Neuron, Li et al. (2019) demonstrate that ZIKV protease NS2B-NS3 heterodimers cleave Septin-2 and lead to cytokinesis defects.
摘要
寨卡病毒（ZIKV）破坏神经发生并导致小头畸形的机制尚未完全阐明。在本期《神经元》杂志上，Li 等人（2019 年）表明，ZIKV 蛋白酶 NS2B-NS3 异二聚体切割 Septin-2 并导致胞质分裂缺陷。
Zotero 插件