1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
2 Affinity Therapeutics, LLC, Cleveland, OH 44106, USA.
Exp Biol Med (Maywood). 2019 Apr;244(6):526-533. doi: 10.1177/1535370219837905. Epub 2019 Mar 21.
Amphotericin B (AmB) is an effective and commonly used antifungal agent. However, nephrotoxicity and poor solubility limits its usage. The proposed polymerized cyclodextrin (pCD) system therefore is an attractive method for AmB delivery, as it retains the antifungal activity of AmB while decreasing toxicity, and confining drug release to the local environment. This system could potentially be used for both prevention and treatment of established fungal infections, as AmB is toxic to fungus whether associated or released from pCD.
两性霉素 B(AmB)是一种有效的、常用的抗真菌药物。然而,其肾毒性和较差的溶解性限制了它的使用。因此,所提出的聚合环糊精(pCD)系统是一种有吸引力的 AmB 给药方法,因为它保留了 AmB 的抗真菌活性,同时降低了毒性,并将药物释放限制在局部环境中。该系统有可能用于预防和治疗已建立的真菌感染,因为 AmB 对真菌有毒,无论是否与 pCD 相关或从 pCD 中释放。