人乳头瘤病毒在泰国患有肛门生殖器疣的女性和男性中的情况。
Human Papillomavirus in Thai Women and Men with Anogenital Warts.
机构信息
Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
出版信息
Intervirology. 2018;61(5):223-229. doi: 10.1159/000497351. Epub 2019 Mar 22.
OBJECTIVE
Anogenital warts are caused by human papillomavirus (HPV). Globally, HPV genotypes 6 and 11 are most often associated with anogenital warts. However, the diversity of HPV genotypes found in patients with genital warts in Thailand is unknown. The aim of this study was to investigate HPV-associated anogenital warts in the Thai population and to assess whether genotypes found are represented in the bivalent and quadrivalent HPV vaccine.
METHODS
This study included 206 anogenital swab samples from patients who were diagnosed with anogenital warts. Detection of HPV DNA was performed using polymerase chain reaction to amplify the L1 gene and sequencing.
RESULTS
HPV was identified in 88.3% (182/206) of the samples. The majority of HPV genotypes were low-risk genotypes HPV6 (36.9%) and HPV11 (36.4%), which represented the most common infection found in genital warts in this study.
CONCLUSION
Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.
目的
肛门生殖器疣是由人乳头瘤病毒（HPV）引起的。在全球范围内，HPV 基因型 6 和 11 与肛门生殖器疣最相关。然而，在泰国患有生殖器疣的患者中发现的 HPV 基因型的多样性尚不清楚。本研究旨在调查泰国人群中与 HPV 相关的肛门生殖器疣，并评估在二价和四价 HPV 疫苗中发现的基因型是否存在。
方法
本研究纳入了 206 例经诊断患有肛门生殖器疣的患者的肛门生殖器拭子样本。使用聚合酶链反应（PCR）扩增 L1 基因并进行测序来检测 HPV DNA。
结果
在 88.3%（182/206）的样本中检测到 HPV。大多数 HPV 基因型为低危型 HPV6（36.9%）和 HPV11（36.4%），这两种基因型是本研究中发现的最常见的生殖器疣感染。
结论
接种四价疫苗（HPV6、HPV11、HPV16 和 HPV18）可能预防由 HPV 感染引起的生殖器疣。
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