Fournier Quentin, Bavcar Spela, Philbey Adrian W, Smith Sionagh, Varjonen Katarina
Department of Small Animal Teaching Hospital, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, EH25 9RG, Scotland, UK.
Department of Easter Bush Pathology, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, EH25 9RG, Scotland, UK.
Vet Dermatol. 2019 Aug;30(4):342-e98. doi: 10.1111/vde.12745. Epub 2019 Mar 25.
Exfoliative dermatitis is a well-recognized cutaneous paraneoplastic syndrome (PNS) associated with thymoma in cats, of which the clinical and histopathological presentation has been well-characterized.
To describe a novel clinical skin manifestation associated with thymoma in a cat.
A 14-year-old neutered female domestic short hair cat.
Physical, abdominal ultrasonographic, thoracic radiographic, ultrasonographic and computed tomographic examinations, histopathological assessment of the skin and mediastinal mass.
The cat was presented with noninflammatory alopecia, with a dorsal multifocal distribution. Examination of the alopecic areas using a dermascope indicated an apparent lack of follicular ostia. Histopathological assessment of alopecic areas confirmed follicular and epidermal atrophy, trichilemmal keratinization and mild orthokeratotic hyperkeratosis. Diagnostic imaging revealed a mediastinal mass, which was surgically removed. Histopathological and immunohistopathological examination of the mass was consistent with a thymoma, associated with multiloculated cyst formation and multifocal cholesterol granulomas. Following surgery, hair re-growth was noted in the previously alopecic areas. The cat was euthanized 3.5 months later because of recurrent chylothorax suspected to be a postoperative complication. The alopecic lesions had improved markedly.
Thymoma-associated PNS might not always manifest as an exfoliative dermatitis and should be considered in the differential diagnosis of multifocal noninflammatory alopecia.
剥脱性皮炎是一种已被充分认识的猫皮肤副肿瘤综合征（PNS），与胸腺瘤相关，其临床和组织病理学表现已得到充分描述。
描述一只猫与胸腺瘤相关的一种新的临床皮肤表现。
一只14岁已绝育的雌性家养短毛猫。
体格检查、腹部超声检查、胸部X线检查、超声检查和计算机断层扫描检查、皮肤和纵隔肿块的组织病理学评估。
这只猫出现非炎性脱毛，呈背部多灶性分布。用皮肤镜检查脱毛区域显示明显缺乏毛囊口。脱毛区域的组织病理学评估证实毛囊和表皮萎缩、毛鞘角化和轻度正角化性角化过度。诊断性影像学检查发现纵隔肿块，手术切除。肿块的组织病理学和免疫组织病理学检查与胸腺瘤一致，伴有多房性囊肿形成和多灶性胆固醇肉芽肿。手术后，先前脱毛区域有毛发生长。这只猫在3.5个月后因怀疑是术后并发症的复发性乳糜胸而实施安乐死。脱毛病变明显改善。
胸腺瘤相关的PNS可能并不总是表现为剥脱性皮炎，在多灶性非炎性脱毛的鉴别诊断中应予以考虑。
