Ashton Melanie M, Dean Olivia M, Walker Adam J, Bortolasci Chiara C, Ng Chee H, Hopwood Malcolm, Harvey Brian H, Möller Marisa, McGrath John J, Marx Wolfgang, Turner Alyna, Dodd Seetal, Scott James G, Khoo Jon-Paul, Walder Ken, Sarris Jerome, Berk Michael
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.
Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.
Front Psychiatry. 2019 Mar 13;10:115. doi: 10.3389/fpsyt.2019.00115. eCollection 2019.
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that . (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.
对于包括双相情感障碍和精神分裂症在内的严重精神疾病，迫切需要新的治疗方法。本综述提出，山竹果皮可能是治疗这些疾病的辅助治疗药物。迄今为止的研究表明，山竹果皮的神经生物学特性与目前对双相情感障碍和精神分裂症病理生理学的理解高度吻合。山竹果皮具有抗氧化、假定的神经保护、抗炎和假定的线粒体增强特性，动物研究表明其在治疗这些疾病方面具有良好的药物治疗效果。本综述总结了其特性的证据，并支持未来开展研究以评估山竹果皮作为情绪和精神障碍辅助治疗选择的效用。
