1 UT Southwestern Medical Center, Dallas, Texas, USA.
2 University of Kentucky, Lexington, Kentucky, USA.
Otolaryngol Head Neck Surg. 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917.
This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation provides evidence-based recommendations on the pre-, intra-, and postoperative care and management of children 1 to 18 years of age under consideration for tonsillectomy. Tonsillectomy is defined as a surgical procedure performed with or without adenoidectomy that completely removes the tonsil, including its capsule, by dissecting the peritonsillar space between the tonsil capsule and the muscular wall. Tonsillectomy is one of the most common surgical procedures in the United States, with 289,000 ambulatory procedures performed annually in children <15 years of age, based on the most recent published data. This guideline is intended for all clinicians in any setting who interact with children who may be candidates for tonsillectomy.
The purpose of this multidisciplinary guideline is to identify quality improvement opportunities in managing children under consideration for tonsillectomy and to create explicit and actionable recommendations to implement these opportunities in clinical practice. Specifically, the goals are to educate clinicians, patients, and/or caregivers regarding the indications for tonsillectomy and the natural history of recurrent throat infections. Additional goals include the following: optimizing the perioperative management of children undergoing tonsillectomy, emphasizing the need for evaluation and intervention in special populations, improving the counseling and education of families who are considering tonsillectomy for their children, highlighting the management options for patients with modifying factors, and reducing inappropriate or unnecessary variations in care. Children aged 1 to 18 years under consideration for tonsillectomy are the target patient for the guideline. For this guideline update, the American Academy of Otolaryngology-Head and Neck Surgery Foundation selected a panel representing the fields of nursing, anesthesiology, consumers, family medicine, infectious disease, otolaryngology-head and neck surgery, pediatrics, and sleep medicine.
The guideline update group made strong recommendations for the following key action statements (KASs): (1) Clinicians should recommend watchful waiting for recurrent throat infection if there have been <7 episodes in the past year, <5 episodes per year in the past 2 years, or <3 episodes per year in the past 3 years. (2) Clinicians should administer a single intraoperative dose of intravenous dexamethasone to children undergoing tonsillectomy. (3) Clinicians should recommend ibuprofen, acetaminophen, or both for pain control after tonsillectomy. The guideline update group made recommendations for the following KASs: (1) Clinicians should assess the child with recurrent throat infection who does not meet criteria in KAS 2 for modifying factors that may nonetheless favor tonsillectomy, which may include but are not limited to multiple antibiotic allergies/intolerance, PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis), or history of >1 peritonsillar abscess. (2) Clinicians should ask caregivers of children with obstructive sleep-disordered breathing and tonsillar hypertrophy about comorbid conditions that may improve after tonsillectomy, including growth retardation, poor school performance, enuresis, asthma, and behavioral problems. (3) Before performing tonsillectomy, the clinician should refer children with obstructive sleep-disordered breathing for polysomnography if they are <2 years of age or if they exhibit any of the following: obesity, Down syndrome, craniofacial abnormalities, neuromuscular disorders, sickle cell disease, or mucopolysaccharidoses. (4) The clinician should advocate for polysomnography prior to tonsillectomy for obstructive sleep-disordered breathing in children without any of the comorbidities listed in KAS 5 for whom the need for tonsillectomy is uncertain or when there is discordance between the physical examination and the reported severity of obstructive sleep-disordered breathing. (5) Clinicians should recommend tonsillectomy for children with obstructive sleep apnea documented by overnight polysomnography. (6) Clinicians should counsel patients and caregivers and explain that obstructive sleep-disordered breathing may persist or recur after tonsillectomy and may require further management. (7) The clinician should counsel patients and caregivers regarding the importance of managing posttonsillectomy pain as part of the perioperative education process and should reinforce this counseling at the time of surgery with reminders about the need to anticipate, reassess, and adequately treat pain after surgery. (8) Clinicians should arrange for overnight, inpatient monitoring of children after tonsillectomy if they are <3 years old or have severe obstructive sleep apnea (apnea-hypopnea index ≥10 obstructive events/hour, oxygen saturation nadir <80%, or both). (9) Clinicians should follow up with patients and/or caregivers after tonsillectomy and document in the medical record the presence or absence of bleeding within 24 hours of surgery (primary bleeding) and bleeding occurring later than 24 hours after surgery (secondary bleeding). (10) Clinicians should determine their rate of primary and secondary posttonsillectomy bleeding at least annually. The guideline update group made a strong recommendation against 2 actions: (1) Clinicians should not administer or prescribe perioperative antibiotics to children undergoing tonsillectomy. (2) Clinicians must not administer or prescribe codeine, or any medication containing codeine, after tonsillectomy in children younger than 12 years. The policy level for the recommendation about documenting recurrent throat infection was an option: (1) Clinicians may recommend tonsillectomy for recurrent throat infection with a frequency of at least 7 episodes in the past year, at least 5 episodes per year for 2 years, or at least 3 episodes per year for 3 years with documentation in the medical record for each episode of sore throat and ≥1 of the following: temperature >38.3°C (101°F), cervical adenopathy, tonsillar exudate, or positive test for group A beta-hemolytic streptococcus.
Incorporating new evidence profiles to include the role of patient preferences, confidence in the evidence, differences of opinion, quality improvement opportunities, and any exclusion to which the action statement does not apply. There were 1 new clinical practice guideline, 26 new systematic reviews, and 13 new randomized controlled trials included in the current guideline update. Inclusion of 2 consumer advocates on the guideline update group. Changes to 5 KASs from the original guideline: KAS 1 (Watchful waiting for recurrent throat infection), KAS 3 (Tonsillectomy for recurrent infection with modifying factors), KAS 4 (Tonsillectomy for obstructive sleep-disordered breathing), KAS 9 (Perioperative pain counseling), and KAS 10 (Perioperative antibiotics). Seven new KASs: KAS 5 (Indications for polysomnography), KAS 6 (Additional recommendations for polysomnography), KAS 7 (Tonsillectomy for obstructive sleep apnea), KAS 12 (Inpatient monitoring for children after tonsillectomy), KAS 13 (Postoperative ibuprofen and acetaminophen), KAS 14 (Postoperative codeine), and KAS 15a (Outcome assessment for bleeding). Addition of an algorithm outlining KASs. Enhanced emphasis on patient and/or caregiver education and shared decision making.
本指南更新版旨在确定在考虑行扁桃体切除术的儿童管理中改善质量的机会,并制定明确和可操作的建议,以便在临床实践中实施这些机会。具体而言,目标是教育临床医生、患者和/或照护者有关扁桃体切除术适应证和复发性喉咙感染自然史的知识。其他目标包括:优化行扁桃体切除术儿童的围手术期管理,强调特殊人群评估和干预的必要性,改善正在考虑为其孩子行扁桃体切除术家庭的咨询和教育,突出有影响因素患者的管理选择,并减少护理中不适当或不必要的差异。本指南的目标患者为 1 至 18 岁考虑行扁桃体切除术的儿童。为此,美国耳鼻喉科学-头颈外科学会基金会选择了一个代表护理、麻醉学、消费者、家庭医学、传染病学、耳鼻喉科-头颈外科学、儿科学和睡眠医学领域的小组。
指南更新组对以下关键行动声明(KAS)做出了强烈推荐:(1)如果过去 1 年中发生咽痛的次数<7 次、过去 2 年中每年咽痛次数<5 次或过去 3 年中每年咽痛次数<3 次,临床医生应建议对复发性喉咙感染进行观察等待。(2)临床医生应在行扁桃体切除术的儿童中给予单次术中静脉用地塞米松。(3)临床医生应建议在扁桃体切除术后使用布洛芬、对乙酰氨基酚或两者联合用于控制疼痛。指南更新组做出了以下 KAS 的推荐:(1)如果符合 KAS 2 中无影响因素但仍可能支持行扁桃体切除术的儿童,应评估复发性喉咙感染患儿,这些影响因素可能包括但不限于多种抗生素过敏/不耐受、周期性发热、口疮性口炎、咽炎和颈淋巴结炎(PFAPA)或过去 1 次以上扁桃体周围脓肿。(2)如果患有阻塞性睡眠呼吸障碍且扁桃体肿大的儿童存在可能在扁桃体切除术后改善的合并症,包括生长迟缓、学习成绩不佳、遗尿、哮喘和行为问题,临床医生应询问照护者。(3)如果儿童年龄<2 岁或存在肥胖、唐氏综合征、头面部畸形、神经肌肉疾病、镰状细胞病或黏多糖贮积症等任何一种合并症,在进行扁桃体切除术之前,临床医生应安排进行多导睡眠图检查以确定是否存在阻塞性睡眠呼吸暂停。(4)如果儿童不存在 KAS 5 中列出的合并症,或需要行扁桃体切除术的必要性不确定,或体格检查与报告的阻塞性睡眠呼吸暂停严重程度不一致,临床医生应主张在进行扁桃体切除术之前,通过多导睡眠图检查来评估阻塞性睡眠呼吸暂停。(5)对于通过夜间多导睡眠图检查确诊的阻塞性睡眠呼吸暂停儿童,临床医生应建议行扁桃体切除术。(6)临床医生应向患者和照护者提供咨询,并解释阻塞性睡眠呼吸暂停可能在扁桃体切除术后持续或复发,并可能需要进一步治疗。(7)临床医生应在围手术期教育过程中向患者和照护者提供管理扁桃体切除术后疼痛的指导,并在手术时通过提醒注意术后疼痛的预期、再评估和充分治疗来加强这种咨询。(8)如果儿童年龄<3 岁或患有严重阻塞性睡眠呼吸暂停(阻塞性事件/小时≥10 次、氧饱和度最低<80%或两者兼有),临床医生应安排在扁桃体切除术后进行过夜、住院监测。(9)临床医生应在扁桃体切除术后随访患者和/或照护者,并记录术后 24 小时内(原发性出血)和术后 24 小时后(继发性出血)有无出血。(10)临床医生应至少每年确定其原发性和继发性扁桃体切除术后出血的发生率。指南更新组强烈反对以下 2 项措施:(1)临床医生不应在行扁桃体切除术的儿童中给予或开具围手术期抗生素。(2)临床医生必须不在行扁桃体切除术的 12 岁以下儿童中给予或开具可待因或含有可待因的任何药物。对于记录复发性喉咙感染的建议的政策级别为选项:(1)临床医生可以建议对咽痛发作频率至少为每年 7 次、每年 5 次持续 2 年或每年 3 次持续 3 年,且每次发作均有体温>38.3°C(101°F)、颈淋巴结肿大、扁桃体渗出物或 A 组β溶血性链球菌阳性检测结果之一的儿童行扁桃体切除术。
纳入新的证据概况,包括患者偏好、对证据的信心、意见分歧、改善质量的机会以及不适用于行动声明的任何排除情况。目前的指南更新版包括 1 项新的临床实践指南、26 项新的系统评价和 13 项新的随机对照试验。指南更新组中增加了 2 名消费者倡导者。从原始指南更新了 5 项 KAS:KAS 1(复发性喉咙感染的观察等待)、KAS 3(有影响因素的复发性感染的扁桃体切除术)、KAS 4(阻塞性睡眠呼吸暂停的扁桃体切除术)、KAS 9(围手术期疼痛咨询)和 KAS 10(围手术期抗生素)。新增 7 项 KAS:KAS 5(多导睡眠图检查适应证)、KAS 6(多导睡眠图检查的其他建议)、KAS 7(阻塞性睡眠呼吸暂停的扁桃体切除术)、KAS 12(扁桃体切除术后住院监测)、KAS 13(术后布洛芬和对乙酰氨基酚)、KAS 14(术后可待因)和 KAS 15a(出血结局评估)。添加了一个概述 KAS 的算法。增强了对患者和/或照护者教育和共同决策的重视。