黄芪通痹汤通过 HMGB1/TLR/NF-κB 通路减轻心肌缺血再灌注损伤。
Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-B Pathway.
机构信息
Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Mediators Inflamm. 2019 Mar 3;2019:8387636. doi: 10.1155/2019/8387636. eCollection 2019.
The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored with the treatment of HQTBT. Triphenyltetrazole chloride (TTC) staining and pathological analysis showed that HQTBT reduced myocardial injury. Besides, the expressions of HMGB1/TLR/NF-B pathway in rats were significantly decreased by HQTBT. This study shows that HQTBT inhibited inflammatory reaction on myocardial injury in rats.
本研究旨在探讨黄芪通痹汤（HQTBT）对大鼠心脏的保护作用。采用冠状动脉结扎法建立缺血再灌注损伤模型，XFZY 可降低冠状动脉结扎大鼠促炎细胞因子水平，同时恢复 ST 段。氯化三苯基四氮唑（TTC）染色和病理分析表明，HQTBT 可减轻心肌损伤。此外，HQTBT 还可降低大鼠心肌组织中高迁移率族蛋白 1（HMGB1）/Toll 样受体（TLR）/核因子-κB（NF-κB）通路的表达。本研究表明，HQTBT 可抑制大鼠心肌损伤的炎症反应。
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