miR-124-3p表达降低通过靶向MGAT5促进乳腺癌的增殖和转移。
Decreased miR-124-3p promoted breast cancer proliferation and metastasis by targeting MGAT5.
作者信息
Yan Guiling, Li Yinhui, Zhan Lu, Sun Shuhan, Yuan Jihang, Wang Tiantian, Yin Yupeng, Dai Zhihui, Zhu Yiqing, Jiang Zhijing, Liu Lin, Fan Yinxing, Yang Fu, Hu Wei
机构信息
Department of Breast and Thyroid Surgery, Changhai Hospital, The Naval Military Medical University Shanghai 200433, China.
Department of General Surgery, The Naval Hospital, Eastern Theater PLA Zhoushan 316000, Zhejiang, China.
出版信息
Am J Cancer Res. 2019 Mar 1;9(3):585-596. eCollection 2019.
Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Numerous studies have indicated that N-acetylglucosaminyltransferase V (MGAT5), is an important tumorigenesis and metastasis-associated enzyme in breast cancer (BC). But, the underlying molecular mechanisms by which ncRNAs modulate MGAT5 expression in BC remain undetermined. In this study, we demonstrated that miR-124 expression at a low level in BC tissue was associated with poor prognosis of BC patients. Meanwhile, miR-124 reduced BC cell proliferation and metastasis. MGAT5 was confirmed as a direct target of miR-124. MGAT5 restoration attenuated the inhibitory effects of miR-124 on BC proliferation and metastasis in and . Overall, we provide new insight into the mechanisms by which miR-124 inhibits BC progression, suggesting the potential of miR-124 and MGAT5 as biomarkers for early diagnosis of breast cancer to provide innovative ideas and methods for the diagnosis and treatment of BC.
非编码RNA（ncRNAs）已被证明可调节多种恶性肿瘤进展过程中涉及的基因表达。大量研究表明，N-乙酰葡糖胺基转移酶V（MGAT5）是乳腺癌（BC）中一种重要的肿瘤发生和转移相关酶。但是，ncRNAs调节BC中MGAT5表达的潜在分子机制仍未明确。在本研究中，我们证明BC组织中miR-124低水平表达与BC患者的不良预后相关。同时，miR-124降低了BC细胞的增殖和转移。MGAT5被确认为miR-124的直接靶点。MGAT5的恢复减弱了miR-124对BC增殖和转移的抑制作用。总体而言，我们为miR-124抑制BC进展的机制提供了新的见解，提示miR-124和MGAT5作为乳腺癌早期诊断生物标志物的潜力，为BC的诊断和治疗提供创新思路和方法。
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