Jang Jong Dae, Do Changwoo, Bang Joona, Han Young Soo, Kim Tae-Hwan
Neutron Science Research Center, Korea Atomic Energy Research Institute, 1045 Daedeok-daero, Yuseong-gu, Daejeon 34057, Korea.
Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Sungbuk-gu, Seoul 02841, Korea.
Polymers (Basel). 2019 Jan 4;11(1):63. doi: 10.3390/polym11010063.
A self-assembled unilamellar vesicle, which can be used as a drug delivery system, was easily and simply fabricated using a blended system of Pluronic block copolymers. Controlling the hydrophilic mass fraction of block copolymers (by blending the block copolymer with a different hydrophilic mass fraction) and temperature (i.e., the hydrophobic interaction is controlled), a vesicular structure was formed. Small angle neutron scattering measurements showed that the vesicular structure had diameters of empty cores from 13.6 nm to 79.6 nm, and thicknesses of the bilayers from 2.2 nm to 8.7 nm when the hydrophobic interaction was changed. Therefore, considering that the temperature of the vesicle formation is controllable by the concentration of the blended block copolymers, it is possible for them to be applied in a wide range of potential applications, for example, as nanoreactors and nanovehicles.
一种可作为药物递送系统的自组装单层囊泡，通过使用普朗尼克嵌段共聚物的混合体系轻松简便地制备而成。通过控制嵌段共聚物的亲水质量分数（通过将具有不同亲水质量分数的嵌段共聚物混合）和温度（即控制疏水相互作用），形成了囊泡结构。小角中子散射测量表明，当疏水相互作用改变时，囊泡结构的空核直径为13.6纳米至79.6纳米，双层厚度为2.2纳米至8.7纳米。因此，考虑到囊泡形成温度可通过混合嵌段共聚物的浓度来控制，它们有可能应用于广泛的潜在应用中，例如作为纳米反应器和纳米载体。
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