从 根部分离得到的二萜类化合物及其抗炎活性。
Diterpenoids isolated from the root of and their anti-inflammatory activity.
机构信息
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea.
College of Natural Sciences, Kangwon National University, Gangwon-do, Republic of Korea.
出版信息
Nat Prod Res. 2021 Mar;35(5):726-732. doi: 10.1080/14786419.2019.1596098. Epub 2019 Apr 9.
Four new diterpene-type compounds normiltirone () and isosalviamides F-H (-) together with twelve known compounds (, , -) were isolated from the roots of . Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound showed a strong inhibitory effect, with an IC value of 3.4 ± 1.2 μM.
从根中分离得到四个新的二萜类化合物normiltirone () 和 isosalviamides F-H (-) 以及十二个已知化合物 (,, -)。它们的结构主要通过详细的光谱数据阐明。所有分离得到的化合物均进行了 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮生成抑制活性评价。化合物 表现出很强的抑制活性，IC 值为 3.4 ± 1.2 μM。
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