多层利多卡因和肾上腺素洗脱PLGA/胶原蛋白纳米纤维的制备：体外和体内研究
Fabrication of Multi-Layered Lidocaine and Epinephrine-Eluting PLGA/Collagen Nanofibers: In Vitro and In Vivo Study.
作者信息
Lee Fu-Ying, Lee Demei, Lee Tzu-Chia, Chen Jan-Kan, Wu Ren-Chin, Liu Kuan-Chieh, Liu Shih-Jung
机构信息
Department of Periodontics, Division of Dentistry, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan.
Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, Taiwan.
出版信息
Polymers (Basel). 2017 Sep 5;9(9):416. doi: 10.3390/polym9090416.
This study developed multi-layered lidocaine- and epinephrine-eluting biodegradable poly[(d,l)-lactide--glyco lide] (PLGA)/collagen nanofibers. An electrospinning technique was employed to fabricate the multi-layer biodegradable drug-eluting nanofibers. After fabrication, the nanofibrous membranes were characterized. The drug release characteristics were also investigated. In addition, the in vivo efficacy of nanofibers for pain relief and hemostasis in palatal oral wounds of rabbits were evaluated. Histological examinations were also completed. The experimental results suggested that all nanofibers exhibited good biocompatibility and eluted effective levels of lidocaine and epinephrine at the initial stages of wound recovery.
本研究制备了多层可生物降解的、负载利多卡因和肾上腺素的聚（d，l）-丙交酯-乙交酯共聚物（PLGA）/胶原纳米纤维。采用静电纺丝技术制备多层可生物降解的药物洗脱纳米纤维。制备完成后，对纳米纤维膜进行了表征。还研究了药物释放特性。此外，评估了纳米纤维对兔腭部口腔伤口止痛和止血的体内疗效。还完成了组织学检查。实验结果表明，所有纳米纤维均表现出良好的生物相容性，并在伤口恢复初期释放出有效水平的利多卡因和肾上腺素。
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